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High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring.

Molecular metabolism

de Castro Barbosa T, Ingerslev LR, Alm PS, Versteyhe S, Massart J, Rasmussen M, Donkin I, Sjögren R, Mudry JM, Vetterli L, Gupta S, Krook A, Zierath JR, Barrès R.
PMID: 26977389
Mol Metab. 2015 Dec 25;5(3):184-197. doi: 10.1016/j.molmet.2015.12.002. eCollection 2016 Mar.

OBJECTIVES: Chronic and high consumption of fat constitutes an environmental stress that leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally remodels the epigenome of spermatozoa and metabolism of the offspring.METHODS: F0-male rats fed either HFD or...

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de Castro Barbosa T, Ingerslev LR, Alm PS, et al. High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring. Mol Metab. 2015;5(3):184-197doi: 10.1016/j.molmet.2015.12.002.
de Castro Barbosa, T., Ingerslev, L. R., Alm, P. S., Versteyhe, S., Massart, J., Rasmussen, M., Donkin, I., Sjögren, R., Mudry, J. M., Vetterli, L., Gupta, S., Krook, A., Zierath, J. R., & Barrès, R. (2016). High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring. Molecular metabolism, 5(3), 184-197. https://doi.org/10.1016/j.molmet.2015.12.002
de Castro Barbosa, Thais, et al. "High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring." Molecular metabolism vol. 5,3 (2016): 184-197. doi: https://doi.org/10.1016/j.molmet.2015.12.002
de Castro Barbosa T, Ingerslev LR, Alm PS, Versteyhe S, Massart J, Rasmussen M, Donkin I, Sjögren R, Mudry JM, Vetterli L, Gupta S, Krook A, Zierath JR, Barrès R. High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring. Mol Metab. 2015 Dec 25;5(3):184-197. doi: 10.1016/j.molmet.2015.12.002. eCollection 2016 Mar. PMID: 26977389; PMCID: PMC4770269.
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Hunger: The carrot and the stick.

Molecular metabolism

Sternson SM.
PMID: 26844201
Mol Metab. 2015 Oct 26;5(1):1-2. doi: 10.1016/j.molmet.2015.10.002. eCollection 2016 Jan.

No abstract available.

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Sternson SM. Hunger: The carrot and the stick. Mol Metab. 2015;5(1):1-2doi: 10.1016/j.molmet.2015.10.002.
Sternson, S. M. (2016). Hunger: The carrot and the stick. Molecular metabolism, 5(1), 1-2. https://doi.org/10.1016/j.molmet.2015.10.002
Sternson, Scott M. "Hunger: The carrot and the stick." Molecular metabolism vol. 5,1 (2016): 1-2. doi: https://doi.org/10.1016/j.molmet.2015.10.002
Sternson SM. Hunger: The carrot and the stick. Mol Metab. 2015 Oct 26;5(1):1-2. doi: 10.1016/j.molmet.2015.10.002. eCollection 2016 Jan. PMID: 26844201; PMCID: PMC4703830.
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EBF2 promotes the recruitment of beige adipocytes in white adipose tissue.

Molecular metabolism

Stine RR, Shapira SN, Lim HW, Ishibashi J, Harms M, Won KJ, Seale P.
PMID: 26844207
Mol Metab. 2015 Nov 14;5(1):57-65. doi: 10.1016/j.molmet.2015.11.001. eCollection 2016 Jan.

OBJECTIVE: The induction of beige/brite adipose cells in white adipose tissue (WAT) is associated with protection against high fat diet-induced obesity and insulin resistance in animals. The helix-loop-helix transcription factor Early B-Cell Factor-2 (EBF2) regulates brown adipose tissue development....

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Stine RR, Shapira SN, Lim HW, et al. EBF2 promotes the recruitment of beige adipocytes in white adipose tissue. Mol Metab. 2015;5(1):57-65doi: 10.1016/j.molmet.2015.11.001.
Stine, R. R., Shapira, S. N., Lim, H. W., Ishibashi, J., Harms, M., Won, K. J., & Seale, P. (2016). EBF2 promotes the recruitment of beige adipocytes in white adipose tissue. Molecular metabolism, 5(1), 57-65. https://doi.org/10.1016/j.molmet.2015.11.001
Stine, Rachel R, et al. "EBF2 promotes the recruitment of beige adipocytes in white adipose tissue." Molecular metabolism vol. 5,1 (2016): 57-65. doi: https://doi.org/10.1016/j.molmet.2015.11.001
Stine RR, Shapira SN, Lim HW, Ishibashi J, Harms M, Won KJ, Seale P. EBF2 promotes the recruitment of beige adipocytes in white adipose tissue. Mol Metab. 2015 Nov 14;5(1):57-65. doi: 10.1016/j.molmet.2015.11.001. eCollection 2016 Jan. PMID: 26844207; PMCID: PMC4703852.
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Decreased expression of hepatic glucokinase in type 2 diabetes.

Molecular metabolism

Haeusler RA, Camastra S, Astiarraga B, Nannipieri M, Anselmino M, Ferrannini E.
PMID: 25737948
Mol Metab. 2014 Dec 18;4(3):222-6. doi: 10.1016/j.molmet.2014.12.007. eCollection 2015 Mar.

BACKGROUND/OBJECTIVES: Increased endogenous glucose production is a hallmark of type 2 diabetes. Evidence from animal models has suggested that a likely cause of this is increased mRNA expression of glucose 6-phosphatase and phosphoenolpyruvate carboxykinase (encoded by G6PC, PCK1 and...

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Haeusler RA, Camastra S, Astiarraga B, et al. Decreased expression of hepatic glucokinase in type 2 diabetes. Mol Metab. 2014;4(3):222-6doi: 10.1016/j.molmet.2014.12.007.
Haeusler, R. A., Camastra, S., Astiarraga, B., Nannipieri, M., Anselmino, M., & Ferrannini, E. (2015). Decreased expression of hepatic glucokinase in type 2 diabetes. Molecular metabolism, 4(3), 222-6. https://doi.org/10.1016/j.molmet.2014.12.007
Haeusler, Rebecca A, et al. "Decreased expression of hepatic glucokinase in type 2 diabetes." Molecular metabolism vol. 4,3 (2015): 222-6. doi: https://doi.org/10.1016/j.molmet.2014.12.007
Haeusler RA, Camastra S, Astiarraga B, Nannipieri M, Anselmino M, Ferrannini E. Decreased expression of hepatic glucokinase in type 2 diabetes. Mol Metab. 2014 Dec 18;4(3):222-6. doi: 10.1016/j.molmet.2014.12.007. eCollection 2015 Mar. PMID: 25737948; PMCID: PMC4338311.
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Leptin recruits Creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulin-deficient diabetes.

Molecular metabolism

Kim GH, Szabo A, King EM, Ayala J, Ayala JE, Altarejos JY.
PMID: 25737949
Mol Metab. 2014 Dec 19;4(3):227-36. doi: 10.1016/j.molmet.2014.12.006. eCollection 2015 Mar.

OBJECTIVE: Leptin alleviates hyperglycemia in rodent models of Type 1 diabetes by activating leptin receptors within the central nervous system. Here we delineate whether non-canonical leptin signaling through the Creb-regulated transcriptional coactivator 1 (Crtc1) contributes to leptin-dependent improvements in...

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Kim GH, Szabo A, King EM, et al. Leptin recruits Creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulin-deficient diabetes. Mol Metab. 2014;4(3):227-36doi: 10.1016/j.molmet.2014.12.006.
Kim, G. H., Szabo, A., King, E. M., Ayala, J., Ayala, J. E., & Altarejos, J. Y. (2015). Leptin recruits Creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulin-deficient diabetes. Molecular metabolism, 4(3), 227-36. https://doi.org/10.1016/j.molmet.2014.12.006
Kim, Geun Hyang, et al. "Leptin recruits Creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulin-deficient diabetes." Molecular metabolism vol. 4,3 (2015): 227-36. doi: https://doi.org/10.1016/j.molmet.2014.12.006
Kim GH, Szabo A, King EM, Ayala J, Ayala JE, Altarejos JY. Leptin recruits Creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulin-deficient diabetes. Mol Metab. 2014 Dec 19;4(3):227-36. doi: 10.1016/j.molmet.2014.12.006. eCollection 2015 Mar. PMID: 25737949; PMCID: PMC4338314.
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Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes.

Molecular metabolism

Nogiec C, Burkart A, Dreyfuss JM, Lerin C, Kasif S, Patti ME.
PMID: 25737951
Mol Metab. 2015 Jan 02;4(3):151-63. doi: 10.1016/j.molmet.2014.12.012. eCollection 2015 Mar.

OBJECTIVE: Dysregulated muscle metabolism is a cardinal feature of human insulin resistance (IR) and associated diseases, including type 2 diabetes (T2D). However, specific reactions contributing to abnormal energetics and metabolic inflexibility in IR are unknown.METHODS: We utilize flux balance...

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Nogiec C, Burkart A, Dreyfuss JM, et al. Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes. Mol Metab. 2015;4(3):151-63doi: 10.1016/j.molmet.2014.12.012.
Nogiec, C., Burkart, A., Dreyfuss, J. M., Lerin, C., Kasif, S., & Patti, M. E. (2015). Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes. Molecular metabolism, 4(3), 151-63. https://doi.org/10.1016/j.molmet.2014.12.012
Nogiec, Christopher, et al. "Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes." Molecular metabolism vol. 4,3 (2015): 151-63. doi: https://doi.org/10.1016/j.molmet.2014.12.012
Nogiec C, Burkart A, Dreyfuss JM, Lerin C, Kasif S, Patti ME. Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes. Mol Metab. 2015 Jan 02;4(3):151-63. doi: 10.1016/j.molmet.2014.12.012. eCollection 2015 Mar. PMID: 25737951; PMCID: PMC4338313.
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High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene.

Molecular metabolism

Liu J, Ramakrishnan SK, Khuder SS, Kaw MK, Muturi HT, Lester SG, Lee SJ, Fedorova LV, Kim AJ, Mohamed IE, Gatto-Weis C, Eisenmann KM, Conran PB, Najjar SM.
PMID: 25737954
Mol Metab. 2015 Jan 02;4(3):186-98. doi: 10.1016/j.molmet.2014.12.011. eCollection 2015 Mar.

OBJECTIVE: Association between prostate cancer and obesity remains controversial. Allelic deletions of PTEN, a tumor suppressor gene, are common in prostate cancer in men. Monoallelic Pten deletion in mice causes low prostatic intraepithelial neoplasia (mPIN). This study tested the...

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Liu J, Ramakrishnan SK, Khuder SS, et al. High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene. Mol Metab. 2015;4(3):186-98doi: 10.1016/j.molmet.2014.12.011.
Liu, J., Ramakrishnan, S. K., Khuder, S. S., Kaw, M. K., Muturi, H. T., Lester, S. G., Lee, S. J., Fedorova, L. V., Kim, A. J., Mohamed, I. E., Gatto-Weis, C., Eisenmann, K. M., Conran, P. B., & Najjar, S. M. (2015). High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene. Molecular metabolism, 4(3), 186-98. https://doi.org/10.1016/j.molmet.2014.12.011
Liu, Jehnan, et al. "High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene." Molecular metabolism vol. 4,3 (2015): 186-98. doi: https://doi.org/10.1016/j.molmet.2014.12.011
Liu J, Ramakrishnan SK, Khuder SS, Kaw MK, Muturi HT, Lester SG, Lee SJ, Fedorova LV, Kim AJ, Mohamed IE, Gatto-Weis C, Eisenmann KM, Conran PB, Najjar SM. High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene. Mol Metab. 2015 Jan 02;4(3):186-98. doi: 10.1016/j.molmet.2014.12.011. eCollection 2015 Mar. PMID: 25737954; PMCID: PMC4338312.
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Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment.

Molecular metabolism

Hill AA, Anderson-Baucum EK, Kennedy AJ, Webb CD, Yull FE, Hasty AH.
PMID: 26779432
Mol Metab. 2015 Jul 28;4(10):665-77. doi: 10.1016/j.molmet.2015.07.005. eCollection 2015 Oct.

OBJECTIVE: Macrophage accumulation in adipose tissue (AT) during obesity contributes to inflammation and insulin resistance. Recruitment of monocytes to obese AT has been the most studied mechanism explaining this accumulation. However, recent evidence suggests that recruitment-independent mechanisms may also...

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Hill AA, Anderson-Baucum EK, Kennedy AJ, et al. Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment. Mol Metab. 2015;4(10):665-77doi: 10.1016/j.molmet.2015.07.005.
Hill, A. A., Anderson-Baucum, E. K., Kennedy, A. J., Webb, C. D., Yull, F. E., & Hasty, A. H. (2015). Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment. Molecular metabolism, 4(10), 665-77. https://doi.org/10.1016/j.molmet.2015.07.005
Hill, Andrea A, et al. "Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment." Molecular metabolism vol. 4,10 (2015): 665-77. doi: https://doi.org/10.1016/j.molmet.2015.07.005
Hill AA, Anderson-Baucum EK, Kennedy AJ, Webb CD, Yull FE, Hasty AH. Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment. Mol Metab. 2015 Jul 28;4(10):665-77. doi: 10.1016/j.molmet.2015.07.005. eCollection 2015 Oct. PMID: 26779432; PMCID: PMC4588436.
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Glucose intolerance induced by blockade of central FGF receptors is linked to an acute stress response.

Molecular metabolism

Rojas JM, Matsen ME, Mundinger TO, Morton GJ, Stefanovski D, Bergman RN, Kaiyala KJ, Taborsky GJ, Schwartz MW.
PMID: 26266088
Mol Metab. 2015 Jun 04;4(8):561-8. doi: 10.1016/j.molmet.2015.05.005. eCollection 2015 Aug.

OBJECTIVE: Central administration of ligands for fibroblast growth factor receptors (FGFRs) such as fibroblast growth factor-19 (FGF19) and FGF21 exert glucose-lowering effects in rodent models of obesity and type 2 diabetes (T2D). Conversely, intracerebroventricular (icv) administration of the non-selective...

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Rojas JM, Matsen ME, Mundinger TO, et al. Glucose intolerance induced by blockade of central FGF receptors is linked to an acute stress response. Mol Metab. 2015;4(8):561-8doi: 10.1016/j.molmet.2015.05.005.
Rojas, J. M., Matsen, M. E., Mundinger, T. O., Morton, G. J., Stefanovski, D., Bergman, R. N., Kaiyala, K. J., Taborsky, G. J., & Schwartz, M. W. (2015). Glucose intolerance induced by blockade of central FGF receptors is linked to an acute stress response. Molecular metabolism, 4(8), 561-8. https://doi.org/10.1016/j.molmet.2015.05.005
Rojas, Jennifer M, et al. "Glucose intolerance induced by blockade of central FGF receptors is linked to an acute stress response." Molecular metabolism vol. 4,8 (2015): 561-8. doi: https://doi.org/10.1016/j.molmet.2015.05.005
Rojas JM, Matsen ME, Mundinger TO, Morton GJ, Stefanovski D, Bergman RN, Kaiyala KJ, Taborsky GJ, Schwartz MW. Glucose intolerance induced by blockade of central FGF receptors is linked to an acute stress response. Mol Metab. 2015 Jun 04;4(8):561-8. doi: 10.1016/j.molmet.2015.05.005. eCollection 2015 Aug. PMID: 26266088; PMCID: PMC4529498.
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Leptin-deficient mice are not hypothermic, they are anapyrexic.

Molecular metabolism

Fischer AW, Cannon B, Nedergaard J.
PMID: 28180058
Mol Metab. 2016 Nov 09;6(2):173. doi: 10.1016/j.molmet.2016.10.012. eCollection 2017 Feb.

No abstract available.

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Fischer AW, Cannon B, Nedergaard J. Leptin-deficient mice are not hypothermic, they are anapyrexic. Mol Metab. 2016;6(2):173doi: 10.1016/j.molmet.2016.10.012.
Fischer, A. W., Cannon, B., & Nedergaard, J. (2017). Leptin-deficient mice are not hypothermic, they are anapyrexic. Molecular metabolism, 6(2), 173. https://doi.org/10.1016/j.molmet.2016.10.012
Fischer, Alexander W, et al. "Leptin-deficient mice are not hypothermic, they are anapyrexic." Molecular metabolism vol. 6,2 (2017): 173. doi: https://doi.org/10.1016/j.molmet.2016.10.012
Fischer AW, Cannon B, Nedergaard J. Leptin-deficient mice are not hypothermic, they are anapyrexic. Mol Metab. 2016 Nov 09;6(2):173. doi: 10.1016/j.molmet.2016.10.012. eCollection 2017 Feb. PMID: 28180058; PMCID: PMC5279901.
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The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512.

Molecular metabolism

Mziaut H, Mulligan B, Hoboth P, Otto O, Ivanova A, Herbig M, Schumann D, Hildebrandt T, Dehghany J, Sönmez A, Münster C, Meyer-Hermann M, Guck J, Kalaidzidis Y, Solimena M.
PMID: 27656403
Mol Metab. 2016 Jun 10;5(8):656-668. doi: 10.1016/j.molmet.2016.05.015. eCollection 2016 Aug.

OBJECTIVE: Insulin release from pancreatic islet β cells should be tightly controlled to avoid hypoglycemia and insulin resistance. The cortical actin cytoskeleton is a gate for regulated exocytosis of insulin secretory granules (SGs) by restricting their mobility and access...

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Mziaut H, Mulligan B, Hoboth P, et al. The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512. Mol Metab. 2016;5(8):656-668doi: 10.1016/j.molmet.2016.05.015.
Mziaut, H., Mulligan, B., Hoboth, P., Otto, O., Ivanova, A., Herbig, M., Schumann, D., Hildebrandt, T., Dehghany, J., Sönmez, A., Münster, C., Meyer-Hermann, M., Guck, J., Kalaidzidis, Y., & Solimena, M. (2016). The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512. Molecular metabolism, 5(8), 656-668. https://doi.org/10.1016/j.molmet.2016.05.015
Mziaut, Hassan, et al. "The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512." Molecular metabolism vol. 5,8 (2016): 656-668. doi: https://doi.org/10.1016/j.molmet.2016.05.015
Mziaut H, Mulligan B, Hoboth P, Otto O, Ivanova A, Herbig M, Schumann D, Hildebrandt T, Dehghany J, Sönmez A, Münster C, Meyer-Hermann M, Guck J, Kalaidzidis Y, Solimena M. The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512. Mol Metab. 2016 Jun 10;5(8):656-668. doi: 10.1016/j.molmet.2016.05.015. eCollection 2016 Aug. PMID: 27656403; PMCID: PMC5021679.
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Leptin and insulin engage specific PI3K subunits in hypothalamic SF1 neurons.

Molecular metabolism

Sohn JW, Oh Y, Kim KW, Lee S, Williams KW, Elmquist JK.
PMID: 27656404
Mol Metab. 2016 Jun 14;5(8):669-679. doi: 10.1016/j.molmet.2016.06.004. eCollection 2016 Aug.

OBJECTIVE: The ventromedial hypothalamic nucleus (VMH) regulates energy balance and glucose homeostasis. Leptin and insulin exert metabolic effects via their cognate receptors expressed by the steroidogenic factor 1 (SF1) neurons within the VMH. However, detailed cellular mechanisms involved in...

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Sohn JW, Oh Y, Kim KW, et al. Leptin and insulin engage specific PI3K subunits in hypothalamic SF1 neurons. Mol Metab. 2016;5(8):669-679doi: 10.1016/j.molmet.2016.06.004.
Sohn, J. W., Oh, Y., Kim, K. W., Lee, S., Williams, K. W., & Elmquist, J. K. (2016). Leptin and insulin engage specific PI3K subunits in hypothalamic SF1 neurons. Molecular metabolism, 5(8), 669-679. https://doi.org/10.1016/j.molmet.2016.06.004
Sohn, Jong-Woo, et al. "Leptin and insulin engage specific PI3K subunits in hypothalamic SF1 neurons." Molecular metabolism vol. 5,8 (2016): 669-679. doi: https://doi.org/10.1016/j.molmet.2016.06.004
Sohn JW, Oh Y, Kim KW, Lee S, Williams KW, Elmquist JK. Leptin and insulin engage specific PI3K subunits in hypothalamic SF1 neurons. Mol Metab. 2016 Jun 14;5(8):669-679. doi: 10.1016/j.molmet.2016.06.004. eCollection 2016 Aug. PMID: 27656404; PMCID: PMC5021675.
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Showing 1 to 12 of 1026 entries